Zoe played the role of Zoe Carpenter in Hollyoaks from 2006 - 2010. She appeared as a guest on Big Brother's Little Brother and also presented at T4 On The Beach In 2009 she performed a Queen Medley on Children In Need alongside other Hollyoaks cast members. During 2010 Lister appeared in the play 'The Stanhope Sisters' as Kitty Dutton at The Red Hedgehog in Highgate, London. From the 16th of August 2010 until the 4th of December 2010 Zoe toured the UK in the comedy play Teechers as Gail. She appeared as Lady Macbeth at the Liverpool Royal Court in 2012, a performance for which she received critical acclaim. Recently Zoe appeared in the feature film 'Brash Young Turks'. She is currently appearing as Mandy in a UK tour of 'Shady Business'.
With former Hollyoaks co-star Lena Kaur, Zoe has formed a comedy theatrical duo, 'Vicious Kitty' and the pair have performed original sketch comedy pieces at the Hen & Chickens in Islington and Leicester Square Theatre.
She is also starring in the new web series 'Staff Room', written and directed by Ry Mcdermott.
She will return to Hollyoaks reprising the role of Zoe in April 2017.
On 19 August 2008 it was announced that Lister was to do the Great North Run to raise money for the Parkinsons Disease Society. Lister's grandmother was diagnosed with Parkinsons Disease shortly before her death. The 13.1 mile run between Newcastle and South Shields took place on 5 October 2008.
In 2015, she married the musician Rob Castell.
In 2010 Lister won the British Soap Awards for the category of Spectacular Scene of the Year for "The Parachute Jump" scene, and in 2007 and 2008 she was Nominated for the category Sexiest Female at British Soap Awards