The station signed on the air on October 18, 1982 as WBLN (standing for what We BeLieve iN) and aired an analog signal on UHF channel 43. It was founded by Grace Communications, a consortium of members of Peoria's Grace Presbyterian Church. Except for the call sign, it was unrelated to the old WBLN that broadcast on UHF channel 15 in the 1950s. The station first broadcast from studios located on East Empire Street/Illinois Route 9 in Bloomington. The station was a general entertainment independent and first new commercial outlet to sign-on since future sister WMBD hit the airwaves 24 years earlier. Grace Communications sold the station to Midwest Television Associates in 1983. It initially signed on at 9 a.m. running religious shows until noon and low budget and barter shows from noon to midnight. This would be a mix of cartoons, public domain movies, some drama shows, westerns, news from CNN, and exercise shows.
In 1984, the station began signing on at 7 a.m. and began running a block of cartoons from 7 to 9 weekday mornings. Midwest then sold WBLN to local businessman G.J. Robinson in 1985 which changed its call letters to the current WYZZ-TV. The station slightly cut back the religious shows but also began running stronger programming such as more of-network sitcoms, both older and recent. On October 6, 1986, the station joined Fox as a charter affiliate. WYZZ later relocated its operations to a new facility located on East Lincoln Street in Bloomington. The station would eventually be sold to Sinclair Broadcast Group in 1996.
On December 1, 2001, Sinclair and the Nexstar Broadcasting Group (owner of WMBD) entered into a local marketing agreement (LMA) in which WMBD would take over WYZZ's operations. As part of the deal, WYZZ abandoned its Bloomington studios and merged its operations into WMBD's facility in Peoria. In August 2005, a similar agreement would be established between Sinclair's WUHF and Nexstar's WROC-TV in Rochester, New York.
WYZZ broadcasts digitally on UHF channel 28 and (like most Sinclair-owned stations) has been digital-only since February 17, 2009. According to a post on The Peoria Chronicle website, WYZZ and WMBD were planning on terminating the LMA between the two effective April 1, 2010. This move was ultimately not followed through with. On May 15, 2012, Sinclair and Fox agreed to a five-year extension to the network's affiliation agreement with Sinclair's nineteen Fox stations, including WYZZ, allowing them to continue carrying the network's programming until 2017.
Sinclair announced the acquisition of Barrington Broadcasting's stations, including WHOI, on February 28, 2013. On that date, Sinclair made public that it would transfer the WYZZ license (along with that of then-sister station WSYT in Syracuse, New York; it would later be dropped from the plan and sold separately) to Cunningham Broadcasting because the WHOI purchase would violate Federal Communications Commission (FCC) regulations on duopoly ownership. However, nearly all of Cunningham Broadcasting's stock is controlled by trusts in the names of the principal owners of Sinclair. Thus, for all intents and purposes, Sinclair still owns WYZZ. Even with the nominal ownership change (the transaction was finalized on November 22), WMBD will continue to operate WYZZ for the time being.