Wendy came aboard the seaQuest DSV 4600 II in 2021 after the first seaQuest had been destroyed by Captain Nathan Bridger the previous year in an attempt to seal a lava pool that threatened to melt the world's polar caps. When Dr. Kristin Westphalen elected not to sign aboard the new seaQuest, Dr. Smith won the most coveted medical position in the UEO that of the chief medical officer of the flagship.
A doctor of all trades, Wendy only took her residency in psychiatry; with a Ph.D in biophysics; although her passion was parapsychology. Discovering that she had a high psi-factor as a child, Wendy found that she could sense the thoughts and emotions of the people around her. Calling it her "sixth sense", she sometimes wished she didn't have the talent, but usually used it to her advantage, although, she swore that she never probed anyone's thoughts without their permission.
Wendy came from a navy family with both her mother and grandmother serving. Captain Bridger had, not only served under her mother, Lexington Fisher-Smith (aka "Sexy-Lexy Smith"), but also pursued a brief romantic involvement with her before ultimately ending the relationship. However, Bridger's prior interest in her mother didn't stop the captain from developing feelings for Wendy. At first, Wendy resisted the relationship and considered transferring off of seaQuest due to the scandal a relationship with the ship's captain would no doubt present, but, after convincing from both Bridger and Lucas Wolenczak, Wendy decided to remain aboard the ship.
Prior to her relationship with Bridger, Wendy had engaged in a relationship with Clay Marshall, director of a parapsychology facility, who helped her develop her telepathic sense, however, the relationship eventually ended. When Tony Piccolo and Dagwood mysteriously shared a nightmare, Wendy took them to be examined by Marshall. However, Clay had been cybernetically augmented in the years following their relationship and required sentium available in the seaQuest's missiles as blood. Desperate to get the material, Marshall used his previous relationship with Smith to help gain access to the seaQuest, however, he was ultimately foiled.
On May 14, 2022, Wendy, along with the rest of the seaQuest crew were transported to the far distant planet Hyperion, tricked into becoming participants in the Hyperion civil war. Wendy was part of the away team sent from seaQuest to destroy the KrayTak mothership and was able to confirm that Tobias LeConte, who had been captured by the KrayTaks, was the genuine article, not a Stormer clone. With the seaQuest hulled by a barrier mine and their shuttle destroyed, the team looked to be doomed. With no other choice, Captain Bridger activated explosive charges and destroyed the mothership, taking the away team with it.