State Route 353 (SR-353) is a state highway in the northeastern portion of the U.S. state of Tennessee, in the area known as the Tri-Cities region. It connects the community of South Central with the town of Jonesborough.
SR-353 begins at an intersection with SR-107 in South Central as Bailey Bridge Road. Approximately 0.4 miles (0.64 km) from SR-107, the route crosses the Nolichucky River. It continues to the community of Washington College, where Bailey Bridge Road ends and SR-353 becomes Old State Route 34. It meets its northern terminus in Jonesborough, an intersection with SR-81.