Keadle, a dentist by profession, founded Rowan Dental Associates in Rowan County, North Carolina, in 1990. Keadle is also the founder and president of Keadle Professional Properties, a commercial and residential real estate development company.
Keadle was born in Huntington, West Virginia, in 1964. His father, Tom Keadle, is a retired sales manager in the coal mining equipment business, and his mother, Jean Miller Yates is a retired schoolteacher.
From Milton High School he went to the United States Air Force Academy and spent his freshman year there, majoring in chemistry. He received an honorable discharge from the US Air Force, and transferred to West Virginia University for his sophomore and junior years, continuing his undergraduate study of Chemistry. He was granted early acceptance into the WVU School of Dentistry in 1985, and graduated with a Doctorate of Dental Surgery (DDS) in 1989.
Following an unsuccessful campaign for Rowan County Commissioner in 1996, he became active in the Republican Party, serving as county finance chairman and then vice-chairman. In 1998, he won a highly contested primary to become the Republican nominee for Congress in the heavily Democratic 12th congressional district, winning 43% of the vote against incumbent Democrat Mel Watt, the highest percentage ever received by a Republican in that district. In 2000, he won the Republican nomination for the heavily Democratic 23rd Senate district in the North Carolina General Assembly, and narrowly lost in the general election.
He moved to Iredell County in 2003 and ran successfully for County Commissioner there in 2008. He was lauded by colleagues and the press as a strong and dominant conservative voice on the County Board, fighting for leaner budgets, transparent government, and always doing his homework. He did not seek re-election in 2010, and his fellow commissioners honored his service with a special presentation. The Mooresville Tribune reported that Commissioner "Steve Johnson said he and Keadle may have disagreed on the issues, but he always respected Keadle for his honesty and integrity."