It comprises 36 principal investigators, has a budget of C$90 million (2005/6), has over 200 trainees and approximately 600 staff. The Institute conducts research into various forms of cancer (colon, breast, pancreatic, prostate), neurological disorders and brain illnesses, |women's and infants' health, diabetes, developmental biology, stem cell biology and tissue regeneration, mouse models of human disease, genomic medicine and systems biology. The Institute has 100,000 sq ft (9,300 m2) of space and is split between the main hospital and the Joseph and Wolf Lebovic Health Complex.
The Lunenfeld-Tanenbaum Research Institute is a world pioneer in the fields of Systems Biology, Diabetes, and Infectious Bowel Diseases. Its Systems Biology team consistently ranked Top 5 worldwide. Researchers at the Lunenfeld have the highest per capita funding and citations in Canada.
The founding director was Louis Siminovitch (1984–1994), followed by Alan Bernstein (1995–2000), Janet Rossant and Anthony Pawson (2001–2002), Anthony Pawson (2002–2005) and James Woodgett (2005–). Researchers are supported by the Mount Sinai Hospital Foundation, donors and external funding sources including the Canadian Institutes of Health Research, Canadian Cancer Society, Terry Fox Foundation, National Institutes of Health and Genome Canada.