The palatability of a substance is determined by opioid receptor-related processes in the nucleus accumbens and ventral pallidum. The opioid processes involve mu opioid receptors and are present in the rostromedial shell part of the nucleus accumbens on its spiny neurons. This area has been called the "opioid eating site".
The rewardfulness of consumption associated with palatability is dissociable from desire or incentive value which is the motivation to seek out a specific commodity. Desire or incentive value is processed by opioid receptor-related processes in the basolateral amygdala. Unlike the liking palatability for food, the incentive salience wanting is not downregulated by the physiological consequences of food consumption and may be largely independent of homoeostatic processes influencing food intake.
Though the wanting of incentive salience may be informed by palatability it is independent and not necessarily reduced to it. It has been suggested that a third system exists that links opioid processes in the two parts of the brain: "Logically this raises the possibility that a third system, with which the accumbens shell, ventral pallidum, and basolateral amygdala are associated, distributes the affective signals elicited by specific commodities across distinct functional systems to control reward seeking... At present we do not have any direct evidence for a system of this kind, but indirect evidence suggests it may reside within the motivationally rich circuits linking hypothalamic and brainstem viscerogenic structures such as the parabrachial nucleus.
Appetite is controlled by a direct loop and an indirect one. In both the direct and indirect loops there are two feedback mechanisms. First a positive feedback involving its stimulation by palatability food cues, and second, a negative feedback due to satiation and satiety cues following ingestion. In the indirect loop these cues are learnt by association such as meal plate size and work by modulating the potency of the cues of the direct loop. The influence of these processes can exist without subjective awareness.