He starred or appeared in more than 31 major films between 1951 and 2000 (with a break between 1987 and 2000), including films such as "Gadfly", "The Forty-first", Khozhdenie za tri morya ("The Journey Beyond Three Seas", also known as "The Traveler"), in which he played Afanasy Nikitin; "The Captain's Daughter", "The Queen of Spades", "Ne podsuden", "Gospodin Velikyi Novgorod", "The Young Peter the Great," "Karl Marxs: The Early Years," and others.
Strizhenov completed the B. V. Shukin Higher Theater School in 1953 and from 1953 he was actor in the Russian Theater of Drama in Tallinn (in Estonia); From 1954-1955, he acted at the Pushkin Theater in Leningrad, and in 1957 he was at the Screen Actors Theater and Studio in Moscow. From 1966 to 1976 he acted at the Moscow Artists' and Actors' Theater.
Oleg Strizhenov has a Bacon number of 3 (Three Degrees of Separation from Kevin Bacon). Strizhenov was in Gospodin velikiy Novgorod (1984) with Alexander Kuznetsov, who was in Space Cowboys (2000) with Blair Brown, who was in Loverboy (2005) with Kevin Bacon.
Oleg's brother, Gleb, was also an actor and a Distinguished Artist of the Russian Soviet Federated Socialist Republic (1974). Gleb died in 1985. Oleg is the father of the Russian actor, writer, producer, and director Aleksandr Strizhenov.
For his performance in The Queen of Spades (Pikovaia Dama)(1960), Strizhenov received the Large Pushkin Gold Medal and was named Laureate and winner of the Gold Medal of the Irina Arkhipova Fund Musical. He was voted best actor of the year in 1970 for his role as the pilot Egorov in "Nepodsuden". He was named a People's Artist of the Soviet Union in 1988.