Cani was a judge on The Voice of Albania for the first two seasons (2011-2013). She was also a judge on the 4th season of X Factor Albania, in 2015. From 2018, she is a judge on The Voice Kids Albania.
In 2003, Miriam Cani along with 13 other participants auditioned for a spot in the German version of the talent show Popstars and in the end she was voted as one of the winners and became a member of the girl group Preluders. Cani made her first TV appearance in Germany in 1993 in the show "Interaktiv". She participated in the musical "Hair" in Germany and also in the musical ''Ludwig 2" in 2013 in Germany ,and in the musical "Chicago" in Albania, where she played the main role, Roxie Hart. As a television host she hosted Jamba TV Clip Clash and Eclips in Germany, and Festivali i Këngës in Albania. She sang in the FilmHarmonic Night in Germany, and also performed her single Bring the Rain in Fernsehgarten.
She hosted the Albanian national final for the Eurovision Song Contest 2010. Cani herself participated in the Albanian national final for the Eurovision Song Contest 2011 in Germany with the entry "Ende ka shpresë" in a duet with singer Alban Skënderaj, now her husband.