are a class of natural products
that consist of a large macrocyclic lactone
ring to which one or more deoxy sugars
, usually cladinose
, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macrolides belong to the polyketide
class of natural products. Some macrolides have antibiotic
activity and are used as pharmaceutical drugs
US FDA-approved :
Ketolides are a class of antibiotics that are structurally related to the macrolides. They are used to treat respiratory tract infections caused by macrolide-resistant bacteria. Ketolides are especially effective, as they have two ribosomal binding sites.
Fluoroketolides are a class of antibiotics that are structurally related to the ketolides. The fluoroketolides have three ribosomal interaction sites.
This page was last edited on 20 April 2018, at 19:16 (UTC)
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