, also known as lutropin
and sometimes lutrophin
) is a hormone
produced by gonadotropic cells
in the anterior pituitary gland
. In females, an acute rise of LH ("LH surge
") triggers ovulation
and development of the corpus luteum
. In males, where LH had also been called interstitial cell–stimulating hormone
it stimulates Leydig cell
production of testosterone
It acts synergistically with FSH
LH is a heterodimeric glycoprotein. Each monomeric unit is a glycoprotein molecule; one alpha and one beta subunit make the full, functional protein.
Its structure is similar to that of the other glycoprotein hormones, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 glycopeptidic subunits, labeled alpha and beta subunits, that are non-covalently associated (i.e., without any disulfide bridge linking them):
The different composition of these oligosaccharides affects bioactivity and speed of degradation. The biologic half-life of LH is 20 minutes, shorter than that of FSH (3–4 hours) and hCG (24 hours).
The gene for the alpha subunit is located on chromosome 6q12.21.
The luteinizing hormone beta subunit gene is localized in the LHB/CGB gene cluster on chromosome 19q13.32. In contrast to the alpha gene activity, beta LH subunit gene activity is restricted to the pituitary gonadotropic cells. It is regulated by the gonadotropin-releasing hormone from the hypothalamus. Inhibin, activin, and sex hormones do not affect genetic activity for the beta subunit production of LH.
This page was last edited on 19 April 2018, at 05:10.
under CC BY-SA license.