Founded on November 14, 2001, the newly formed Lehigh Valley Conference (LVC) rejoined most of the 12 schools that formerly competed in the East Penn Conference at various times from 1976 to 1997, before five schools left in 1997 to join the Mountain Valley Conference (MVC). (Phillipsburg High School had previously left the East Penn Conference in 1994 to join the Skyland Conference in New Jersey to be eligible for NJISAA football playoffs; Northampton Area High School had joined the MVC for the 1994-95 school year.) Eleven of these schools reunited to form the LVC, along with Nazareth Area High School who had previously competed in the Colonial League before moving to the MVC in 1994. One more former East Penn Conference school, Bethlehem Catholic High School, was admitted to the new conference in February 2002. Conference play began with the 2002-03 school year.
In 2012, the two Allentown public high schools, William Allen and Dieruff, decided to join the MVC as associate members for football only. Then on October 2, 2013, the LVC voted to invite six Monroe County high schools: Stroudsburg Area High School of Stroudsburg, Pennsylvania, East Stroudsburg Area North and South of East Stroudsburg, Pennsylvania, Pocono Mountain East and West of Swiftwater, Pennsylvania and Pleasant Valley Area High School of Brodheadsville, Pennsylvania. The remaining MVC school, Lehighton Area High School, had already announced in 2012 they would join the Schuylkill League.
Among Lehigh Valley Conference schools, Emmaus High School holds the record for most Pennsylvania state championships in all sports since the league's creation. Parkland High School holds the record for the most conference championships in all sports.
Lehigh Valley Conference football, boys and girls basketball games and wrestling matches were broadcast during the respective seasons on Service Electric's Channel 2 in the Lehigh Valley and other broadcast markets. RCN 4, another local television station, also broadcast the Lehigh Valley Conference's football, basketball and wrestling events.
Service Electric also broadcast a weekly "Plays of the Week" segment, sponsored by Yocco's Hot Dogs, which featured the best football, basketball, wrestling and other Lehigh Valley Conference sports highlights of the week.