An army brat born in Germany, Moore attended Houston County High School in Warner Robins, Georgia, where he was named Georgia Class 5A Defensive Player of the Year as a senior defensive lineman. He had 93 tackles, 22 sacks, 18 deflections, 8 forced fumbles, 2 fumble recoveries and 1 blocked punt (for a touchdown) in 2004.
As a junior in 2003, he made All-Middle Georgia, All-Region and All-County while getting 110 tackles, 23 tackles for loss and 15 sacks. Moore was rated a Four-Star recruit and chose USC over Miami.
At USC, Moore served as a backup defensive end as a true freshman and sophomore. In 2007, he did a solid job while starting at defensive end, recording 35 tackles, including 3.5 for losses of 29 yards (with 2 sacks for 20 yards), plus 2 interceptions that he returned 38 yards (19.0 avg.), 5 deflections, 1 forced fumble and 1 fumble recovery.
In 2008 Moore had arthroscopic surgery on his knee prior to 2008 spring practice, which limited him in spring drills. He started at defensive end alongside Everson Griffen.
Moore was one of twelve USC players invited to the 2009 NFL Scouting Combine.