Durand is known for portraying Vasiliy Fet in The Strain, Joshua in Dark Angel, Martin Keamy in Lost, Fred J. Dukes / The Blob in X-Men Origins: Wolverine, Gabriel in Legion, Little John in Robin Hood, Jeeves Tremor in Smokin' Aces, and Carlos in The Butterfly Effect. He received a 2012 Best Supporting Actor Genie nomination for his portrayal of Lenny Jackson in Edwin Boyd: Citizen Gangster.
Durand is a character actor whose first big movie break came when he was cast in Mystery, Alaska. His film credits include the role of Booth in Walking Tall, sidekick Red in Wild Hogs, the psychotic neo-nazi Jeeves Tremor in Smokin' Aces, the title role in Otis E., Gabriel in Legion, Little John in Robin Hood, and the hired thug Tucker in the 2007 remake of 3:10 to Yuma with Russell Crowe and Christian Bale. Recent film successes include, X-Men Origins: Wolverine playing the comic book character Blob and the role of Ricky in Real Steel, both with Hugh Jackman. In 2012, he co-starred in Edwin Boyd: Citizen Gangster and David Cronenberg's Cosmopolis, the latter film opposite Robert Pattinson, Paul Giamatti, and Samantha Morton. He will appear in The Truth with Andy García and Forest Whitaker, and took on video game character Barry Burton in the 5th installment of the Resident Evil movie franchise, Resident Evil: Retribution. Durand's combined box office numbers total over 2.5 billion dollars worldwide. In 2013, he appeared in the film The Mortal Instruments. He co-starred in Darren Aronofsky's Noah and Atom Egoyan's two newest films, Devil's Knot and The Captive. Since 2014, he has starred as Vasiliy Fet in Guillermo del Toro's FX TV series The Strain. In 2015, he stars as Harbard the Wanderer in History Channel's original series Vikings.
Durand has played series regulars on shows such as James Cameron's Dark Angel as Joshua, Agent Jay Swopes in the American remake of Touching Evil, as well as guest roles on CSI, CSI: Miami, ER, Without a Trace, Dead Like Me and others. He also recurred on the television show Stargate SG-1 as "Lord Zipacna" (based on the Mayan mythological figure Zipacna) and on Lost during seasons 4 and 6, in which he played as the antagonist Martin Keamy for 12 episodes.