Like many others men of this period, he began his career in 1336, at the end of the Kenmu Restoration. He fought many battles all over the country, including 1336's attack to Mount Hiei. In 1338, together with cousin Moroyasu, he went to fight against Southern Court forces in Aonohara, Mino Province, to help contain Kitabatake Akiie, who was threatening Kyoto. The next year he was made Kantō shitsuji, counsellor to Ashikaga Yoshiakira, holding the post until 1944. He proved successful in this role against both the pro-Ashikaga Tadayoshi Uesugi clan and against Hitachi Province's Kitabatake Chikafusa, who was the main military force behind the Southern court. He defeated Chikafusa first in December 1341 and then two years later, finally driving him out of Kantō. He was concurrently also shugo of Musashi Province from 1341 to 1344.
He was then ordered to return to Kyoto, and in 1347 sent to Ise Province as shugo, in which role he fought several battles. In 1349 Takauji sent his son Motouji to the Kantō to take the place of his other son Yoshiakira, whom he wanted in Kyoto, stabilize the area and protect his interests there. Since Motouji was then just a child, real power was in the hands of the two shitsuji Uesugi Noriaki and Morofuyu himself, men which were politically enemies. In 1350, during the so-called Kannō disturbance, a civil war that saw the two Ashikaga brothers fight each other, the differences between the two deepened past the breaking point. He remained with Takauji, while Noriaki defected and went with Tadayoshi. In 1351 he left Motouji in Kamakura to attack Noriaki. Defeated and pursued by his forces, he committed seppuku at Suzawa Castle (須沢城) in Kai Province.