This new Hunter × Hunter anime was announced on July 24, 2011. It is a complete reboot of the series starting from the beginning of the manga, with no connections to the first anime from 1999. It is directed by Hiroshi Kōjina, produced by Madhouse, and features scripts by Jun Maekawa and character designs by Takahiro Yoshimatsu. Instead of having the old cast reprise their roles for the new adaptation, the series features an entirely new cast to voice the characters. The new series premiered airing weekly on Nippon Television and the nationwide Nippon News Network from October 2, 2011. An hour after each episode is aired in Japan, American website Crunchyroll provided English subtitled simulcasts in the United States, Canada, the United Kingdom, Ireland, South Africa, Australia, and New Zealand. The series started to be collected in both DVD and Blu-ray format on January 25, 2012. Viz Media has licensed the anime for a DVD/Blu-ray release in North America with an English dub. On television, the series began airing on Adult Swim's Toonami block on April 16, 2016.
The anime series' opening theme is alternated between the song "Departure!" and an alternate version titled "Departure! -Second Version-" both sung by Galneryus' vocalist Masatoshi Ono. Five pieces of music were used as the ending theme; "Just Awake" by the Japanese band Fear, and Loathing in Las Vegas in episodes 1 to 26, "Hunting for Your Dream" by Galneryus in episodes 27 to 58, "Reason" sung by Japanese duo Yuzu in episodes 59 to 75, "Nagareboshi Kirari" also sung by Yuzu from episode 76 to 98, which was originally from the anime film adaptation, Hunter × Hunter: Phantom Rouge, and "Hyōri Ittai" by Yuzu featuring Hyadain from episode 99 to 146, which was also used in the film Hunter × Hunter: The Last Mission. The background music and soundtrack for the series was composed by Yoshihisa Hirano.