Higashi-Kurume Station is served by the Seibu Ikebukuro Line from Ikebukuro in Tokyo, with some services inter-running via the Tokyo Metro Yurakucho Line to Shin-Kiba and the Tokyo Metro Fukutoshin Line to Shibuya and onward via the Tokyu Toyoko Line and Minato Mirai Line to Motomachi-Chukagai. Located between Hibarigaoka and Kiyose, it is 17.8 km from the Ikebukuro terminus.
The station has two ground-level side platforms serving two tracks.
The "Emio Higashi-Kurume" shopping and eating complex opened in 2010. The station building includes lavatories for men and women and a wheelchair-accessible multi-purpose restroom.