Many writers, including Lactantius, Cyprian of Carthage, Augustine, Marsilio Ficino, Giovanni Pico della Mirandola, Giordano Bruno, Campanella, Sir Thomas Browne, and Ralph Waldo Emerson, considered Hermes Trismegistus to be a wise pagan prophet who foresaw the coming of Christianity. St. Thomas Aquinas reported that Trismegistus arrived at something akin to the doctrine of the Trinity.
An account of how Hermes Trismegistus received the name "Thrice Great" is derived from the Emerald Tablet of Hermes Trismegistus, wherein it is stated that he knew the three parts of the wisdom of the whole universe. The three parts of the wisdom are alchemy, astrology, and theurgy.
The Poimandres, from which Marsilio Ficino formed his opinion, states that "They called him Trismegistus because he was the greatest philosopher and the greatest priest and the greatest king." The Suda (10th century) states that "He was called Trismegistus on account of his praise of the trinity, saying there is one divine nature in the trinity."
Much of the importance of Hermeticism arises from its connection with the development of science during the time from 1300 to 1600 AD. The prominence that it gave to the idea of influencing or controlling nature led many scientists to look to magic and its allied arts (e.g., alchemy, astrology) which, it was thought, could put Nature to the test by means of experiments. Consequently, it was the practical aspects of Hermetic writings that attracted the attention of scientists.
Isaac Newton placed great faith in the concept of an unadulterated, pure, ancient doctrine, which he studied vigorously to aid his understanding of the physical world. Many of Newton's manuscripts—most of which are still unpublished—detail his thorough study of the Corpus Hermeticum, writings said to have been transmitted from ancient times, in which the secrets and techniques of influencing the stars and the forces of nature were revealed, i.e. As Above, So Below.