The 2010 Hamilton municipal election was held on October 25, 2010 to select one Mayor, fifteen members of the Hamilton, Ontario City Council and members of both English and French Public and Catholic School Boards. Nominations opened January 4, 2010 and ran until September 10, 2010.
Hamiltonians elected their third mayor in as many elections, choosing former Ward 2 Councillor Bob Bratina over Larry Di Ianni (Mayor 2003-2006) and incumbent Mayor Fred Eisenberger, who had served in the role since 2006. The council election to succeed Bratina in Ward 2 drew 20 candidates, while Ward 14 Councillor Robert Patsuta was acclaimed. Only one incumbent councillor was defeated: Brenda Johnstone defeated long-time Councillor Dave Mitchell in Ward 11. Many Catholic School Board trustees were defeated by first-time candidates.
There was speculation that this election was to include a new 16th Council seat, that would encompass southern portions of Wards 6,7 and 8 and the northern portion of Ward 11. The new ward would have included the area to be developed as part of the controversial "Aerotropolis" industrial development plan, though that plan was abandoned in favour of a study of all ward boundaries following the election.