Born in Stuttgart, Tsinguirides began her ballet training at the ballet school of the Staatstheater Stuttgart. She continued her studies with Olga Preobrajenska at the Studio Wacker in Paris and at the Royal Ballet School in London. Tsinguirides was engaged at the Staatstheater Stuttgart in 1945 and was promoted to soloist in 1957 under ballet director Nicolas Beriozoff. In 1960 she performed in Der Pagodenprinz by John Cranko who later succeeded Beriozoff as director in 1961. She performed in The Lady and the Fool, and in Romeo und Julia.
Cranko sent her to study the Benesh Movement Notation in London, which she completed in 1966. The notation, which shows movements of head, shoulders, hips, knees and feet on five lines similar to music notation, is according to experts still the most precise representation of ballet even in the time of video, offering also the possibility of synchronization with the music. Tsinguirides became the first choreologist in Germany in 1966, and preserved all major ballets by Cranko, and later Kenneth MacMillan, and others. She has been teaching these works several generations of ballet companies internationally, working with 45 ballet groups.