Actress Ann Flood starred as Elizabeth "Liz" Fraser Allen, a successful writer who had returned to her New England hometown of Strathfield to run her family's newspaper, the Strathfield Record. Her father, Ben Fraser, Sr. had suffered a heart attack, thus causing Liz, who had been living and working in Washington, D.C. to come home, leaving her D.C. fiance, Bruce Crawford. Another former beau, from her earlier days in Strathfield, Dr. Buck Weaver, eventually married his secretary, Maggie Barker.
Her family included a brother Ben, Jr. who worked a family farm, was married to Italian Rose Corelli; had three children, including a son, named Dan, and didn't have much to do with the newspaper; and a sister Emily, who was married to Jim Benson and, after Jim's death, to Frank Teton. Jim and Emily had a daughter, named Lyddy, who worked with her aunt Liz on the newspaper.
Liz's first adversary was wealthy Enid Chambers, who was the first wife of the man she would eventually marry, David Allen. Her later adversary was alcoholic actress, Lynn Franklin, who, despite her own marriage to Tom Jennings, was very much in love with David and wanted him for herself.
Several actors featured on From These Roots found fame in later shows. These include Henderson Forsythe (Jim Benson), who went on to fame as Dr. David Stewart on As the World Turns; Charlotte Rae (Hilda Furman), who played Molly the Mail Lady on Sesame Street during the show's third season; and then played her more well-known role of Edna Garrett on Diff'rent Strokes and The Facts of Life; Vera Allen (Kass), later played roles on Another World and Search for Tomorrow; Billie Lou Watt (Maggie Barker Weaver) who played Stu Bergman's second wife, Ellie Harper, on Search for Tomorrow; Audra Lindley (Laura Tompkins), best known as the first landlady, Helen Roper from Three's Company and its spin-off The Ropers (as well as Liz Matthews #3 on Another World; Millette Alexander (Gloria Saxon) later played roles on As the World Turns,The Guiding Light and three roles on The Edge of Night; Robert Mandan (David Allen) who later played pompous and philandering stockbroker Chester Tate on Soap, the highly ineffective Colonel Fielding on the television adaptation of the movie, Private Benjamin and created the role of Sam Reynolds on Search for Tomorrow; Barbara Berjer (Lynn Franklin) who continued serial work, most notably on As the World Turns and Guiding Light; Richard Thomas (Richard), well known as John-Boy Walton #1 from The Waltons as well as other serial roles; Craig Huebing (Tom Jennings), later of General Hospital; Joseph Mascolo (Jack Lander), known for his roles as Stefano DiMera on Days of Our Lives and Massimo Marone on The Bold and the Beautiful; John Karlen, later known as Willie Loomis #2 on Dark Shadows; and Harvey Lacey of Cagney & Lacey; and John Colenback (Jimmy Hull) who played Henderson Forsythe's son, Dr. Dan Stewart, on As the World Turns.
The show was directed by Joseph Behar, and Don Wallace and Paul Lammers, who were producers as well, along with Eugene Barr. It was also known for a storyline dealing with the show-within-a-show performance of Madame Bovary, which heavily featured the show's villainess, Lynn Franklin.