As of the beginning of the 17th century, the running of the Treasury was frequently entrusted to a commission, rather than to a single individual. Since 1714, it has permanently been in commission. The commissioners have always since that date been referred to as Lords Commissioners of the Treasury, and adopted ordinal numbers to describe their seniority. Eventually in the middle of the same century, the First Lord of the Treasury came to be seen as the natural head of the overall ministry running the country, and, as of the time of Robert Walpole (Whig), began to be known, unofficially, as the Prime Minister. The term Prime Minister was initially, but decreasingly, used as a term of derogation: it was first used officially in a royal warrant only in 1905. William Pitt the Younger once opined that the Prime Minister "ought to be the person at the head of the finances."
Prior to 1827 the First Lord of the Treasury also held the office of Chancellor of the Exchequer unless he was a peer and thus barred from that office; in this case, the Second Lord of the Treasury usually served as Chancellor. As of 1827, the Chancellor of the Exchequer has always been Second Lord of the Treasury when he was not also Prime Minister. By convention, the other Lords Commissioners of the Treasury are also Government Whips in the House of Commons.
10 Downing Street is the official residence of the First Lord of the Treasury, and not of the Prime Minister. Chequers, a country house in Buckinghamshire, is the official country residence of the Prime Minister, used as a weekend and holiday home, although the residence is also used by other senior members of government.
Much of this list overlaps with the list of Prime Ministers of the United Kingdom, but there are some notable differences, principally concerning the Marquess of Salisbury, who was Prime Minister but not First Lord in 1885–86, 1887–92 and 1895–1902. Those First Lords who were simultaneously Prime Minister are indicated in bold; those First Lords who were considered Prime Minister only during part of their term are indicated in bold italic.