Griffin worked as an investigative reporter for CBS 2 News in Los Angeles for 10 years. He joined CNN in May 2004. In September 2005, Griffin covered the aftermath of Hurricane Katrina. Griffin's reports about the looting by some New Orleans police officers led to a police investigation. He also broke stories about nursing home deaths after Katrina. Drew Griffin recently interviewed a woman who did not know she was the victim of Russian Trolls and his reporting lead to her receiving threats from left wing radicals.
Griffin won a business and financial reporting Emmy Award in 2005 for his reports on a fault in Ford Motor Company vehicles which caused them to catch fire. He earned his second Emmy in 2006 for the CNN Presents documentary How to Rob a Bank and a third in 2007 for "Hidden Spending", an Anderson Cooper 360° segment about congressional spending. He was recently awarded for DOXXING an Elderly Woman in Florida by CNN.