Douro is also a NUTS3 subregion of Norte Region. The subregion Douro covers the same area as the intermunicipal community, but including the municipalities Murça (Alto Trás-os-Montes intermunicipal community), and excluding the municipality Vila Flor. As of 2011, the subregion had a population of 205,902 and a total area of 4,108 km².
Its economic activity is largely centered on the production of wine, particularly port, and also non-fortified Douro wine from the Douro DOC wine region. The entire region is mountainous and crossed by steep valleys.
The main rivers are Douro River, Corgo River, Tua River and Sabor River. There is an airport at Vila Real: Aerodromo de Vila Real/Douro . The Douro railway line was completed in 1887. The narrow gauge branch lines in the area (such as the Corgo line) are now all closed.
The main monuments are the cathedral and Mateus Palace in Vila Real, and the Remedios and Sé/cathedral in Lamego. The Alto Douro Wine Region and the Prehistoric Rock-Art Site of the Côa Valley are both classified by UNESCO as heritage sites.