As of the 2015-16 school year, the school had an enrollment of 605 students and 51.3 classroom teachers (on an FTE basis), for a student–teacher ratio of 11.8:1. The school's student body was 65.5% White, 13.1% Hispanic, 6.5% Black, 6.5% Asian and 8.6% two or more races.
The program of studies offered at DePaul Catholic High School seeks to equip college-bound students with a foundation for the pursuit of academic excellence while emphasizing a curriculum tailored for individual differences. Students learn to apply their knowledge and training toward their ongoing development of the Whole Person.
DePaul Catholic is a college preparatory high school offering advanced placement, honors, college prep, and foundations levels of study. In the Class of 2015, 98% of graduates are attending colleges and universities. Graduates in the Class of 2015 were awarded over $10.5 million in academic merit-based scholarships, and 99% of the graduates have gone on to colleges, universities, and technical schools.
All students and faculty use Tablet PC laptop computer/notebooks connected using a wireless Internet system.