In 1883, the successful operetta Falka had its London première at the theatre, and in 1885, Erminie did the same. The theatre's reputation grew through the First World War when Charles Blake Cochran and André Charlot presented their famous revue shows. Famous actors who appeared here include Henry Daniell who played John Carlton in Secrets in September 1929.
The theatre was notable for the role it played in overturning stage censorship by establishing the New Watergate Club in 1956, under producer Anthony Field. The Theatres Act 1843 was still in force and required scripts to be submitted for approval by the Lord Chamberlain's Office. Formation of the club allowed plays that had been banned due to language or subject matter to be performed under "club" conditions.
Plays produced in this way included the UK premières of Arthur Miller's A View from the Bridge, Robert Anderson's Tea and Sympathy and Tennessee Williams' Cat On A Hot Tin Roof. The law was not revoked until 1968, but in the late 1950s there was a loosening of conditions in theatre censorship, the club was dissolved and Peter Shaffer's Five Finger Exercise premièred to a public audience.
On 7 September 2011 it was announced that the theatre's owner, Ambassador Theatre Group (ATG) would be renaming the Comedy Theatre to the Harold Pinter Theatre from Thursday 13 October 2011.