The CBD is often also the "city centre" or "downtown", but this is also often not the case. Midtown Manhattan is the largest central business district in New York City and in the world; yet Lower Manhattan, commonly called Downtown Manhattan, represents the second largest distinct CBD in New York City and is geographically situated south of Midtown. For example, London's "city centre" is usually regarded as encompassing the historic City of London and the medieval City of Westminster, whereas the City of London and the transformed Docklands area are regarded as its two CBDs. Mexico City also has a historic city centre, the colonial-era Centro Histórico, along with two CBDs: the mid-late 20th century Paseo de la Reforma - Polanco, and the new Santa Fe. In Taipei, Taiwan, the area around its main railway station is regarded as the historic city centre while the Xinyi Planned Area located to the east of the said railway station is the current CBD of Taipei, being both the financial district and the premier shopping area, and the location of Taipei 101, Taipei's tallest building.
The shape and type of a CBD almost always closely reflect the city's history. Cities with strong preservation laws and maximum building height restrictions to retain the character of the historic and cultural core will have a CBD quite a distance from the center of the city. This is quite common for European cities such as Paris or Vienna. In cities in the New World that grew quickly after the invention of mechanized modes such as road or rail transport, a single central area or downtown will often contain most of the region's tallest buildings and act both as the CBD and the commercial and cultural city centre. Increasing urbanization in the 21st century have developed megacities, particularly in Asia, that will often have multiple CBDs scattered across the urban area. It has been said that downtowns (as understood in North America) are therefore conceptually distinct from both CBDs and city centers. No two CBDs look alike in terms of their spatial shape, however certain geometric patterns in these areas are recurring throughout many cities due to the nature of centralized commercial and industrial activities.
In Australia the acronym CBD is used very commonly to refer to major city centres. It is used in particular to refer to the skyscraper districts in state capital cities such as Melbourne, Brisbane, Perth, Adelaide and Sydney. Sydney is currently Australia's largest CBD with Melbourne second and Brisbane third when judged by number of total buildings.
Melbourne, however, features the most skyscrapers of any Australian city at 36. This is more skyscrapers than Beijing, London or Moscow. Melbourne is also fast growing to overtake Sydney as Australias largest CBD.