She secured funding for an extensive renovation of the White House and oversaw the work. Interested in history and preservation, in 1890 she helped found the National Society of the Daughters of the American Revolution (DAR) and served as its first President General.
Dr. Scott had been at Miami for more than two decades when, in 1845, he and several other professors were fired after a dispute with the university president, George Junkin, over slavery; Junkin supported it and Scott and the others opposed it.
Her father next accepted a job teaching chemistry and physics at Farmer's College and moved the family to College Hill, near Cincinnati. There in 1848 Caroline met Benjamin Harrison, one of her father's freshman students. The two began a courtship but did not marry until 1853.
In 1849, the Scotts returned to Oxford, as Dr. Scott was selected as the first president of the Oxford Female Institute. It was held in the former Temperance Tavern, which he had purchased in 1841. Her mother Mary Neal Scott joined the school as its matron and the Head of Home Economics. Caroline enrolled as a student, studying English literature, theater, art, and painting. In her senior year in 1852, she joined the faculty as an Assistant in Piano Music.