Big Mutha Truckers 2 begins with Ma Jackson, the proprietor of Big Mutha Truckers Haulage, being taken into police custody for tax evasion. The only way she can win her case is by hiring Cousin Jacob, the most "fancy-talkin' legal fella" this side of Booger's Canyon. It's up to you to raise the cash needed to bribe jurors to let Ma off by trucking, trading, wheeling and dealing.
The go-anywhere, any-time philosophy that was utilized in the original Big Mutha Truckers is expanded for Big Mutha Truckers 2 with additional routes, hidden shortcuts, and the ability to drive numerous vehicles. In addition, the trading process has been extremely streamlined, with more focus on the on-road action. Also instead of just law enforcers & motorcycle gangs, (like in the previous installment) you also have UFOs which are after your load if you're not careful during your transporting. But as a difference from the first game, this one uses Free's "All Right Now" instead of Steppenwolf's "Born to Be Wild" for its theme song.
Detroit Free Press gave the Xbox version a score of two stars out of four and stated: "The action is respectable when you're on the road with your 18-wheeler, dodging UFO invaders, smacking sinister bikers with your trailer and outrunning the cops, but the bare-bones production value is clear when you visit towns. You go to stores and bars to buy upgrades, meet people and find your next load to haul." The Sydney Morning Herald gave the PS2 version a score of two-and-a-half stars out of five and said, "Causing havoc behind the wheel of a big rig is fun but the novelty quickly wanes and the unsubtle gags often fail to amuse, especially when they are endlessly repeated." The Times gave the game two stars out of five and said that "The fact that the graphics are so impressive, and the road maps so brilliantly extensive, only adds to the disappointment of the overall experience." Maxim gave it a score of two out of ten and stated that "it ain't nuthin' we ain't seen before. When not running from the cops a la "Driver," you're making deliveries like in "Crazy Taxi"—both of which would be a lot more fun if your rig wasn't slow and sluggish like Eminem with his medicine."