The Blazers were formerly a member National Capital Region Athletic Association (NCRAA) before they applied and were admitted to the NCAA in 1998. They then went on to win their first NCAA seniors basketball title in 2000 was the fastest for an expansion squad.
The other senior varsity teams may also be referred to as the Blazers. The juniors team are the CSB–LSGH Junior Blazers (officially the CSB–LSGH Greenies) of La Salle Green Hills, while the women's teams (volleyball and taekwondo) are the St. Benilde Lady Blazers.
Almost all sports program of the Blazers excel in their events, leading to the De La Salle-College of Saint Benilde winning its first General Championship honors in NCAA Season 81, and again in NCAA Season 83, NCAA Season 84, NCAA Season 89, and NCAA Season 90.
As homage to the school which introduced several pioneering courses in the country, the college adopted the blazer as their moniker. It is a short term for trail blazers, which emphasizes the college's commitment to set a standard for education as well as sports development.
When De La Salle University selected De La Salle Santiago Zobel School as its junior affiliate team when it entered the UAAP in 1986, La Salle Green Hills was left without a membership in either the UAAP or the NCAA, thus starting a 17-year drought in a major collegiate league since its formal withdrawal from the NCAA in 1981.