Belle Reve Federal Penitentiary is a special prison for metahumans and other supervillains located in Terrebonne Parish, Louisiana. Being the prison for many supervillains, it was chosen by Amanda Waller as the base of operations for the Suicide Squad. Criminals can have their prison sentences reduced if they take part in the deadly missions of the Suicide Squad. Some of the more untrustworthy ones are required to carry devices that will cause maiming or death if they try to escape.
Many, but not all of the staff, work both as prison employees and facilitate Suicide Squad operations. Some of the staff are friends with the more level-headed Squad members. Mechanics work on Squad vehicles. Prison doctors treat prisoners and Squad staff alike. The existence of the Squad brings the facility under attack many times.
The prison has been the focus of many governmental investigations, as it would be a scandal to learn that the United States is using murderous supervillains to further its own ends. Noted reporter Lois Lane did an investigation, only partly turned away by a fake warden installed to divert attention away from Suicide Squad activities. Amanda Waller herself served time in Belle Reve when she was convicted on charges stemming from her Suicide Squad operations.
A Belle Reve prison riot is calmed by Superman and the time traveling Kal Kent in DC One Million #1 (Nov. 1998).