The competition was created in 1895 by the Royal Belgian Football Association and was first won by FC Liégeois. Of the 74 clubs to have competed in the first division since its creation, 15 have been crowned champions of Belgium. RSC Anderlecht is the most successful league club with 34 titles, followed by Club Brugge KV (14), Union Saint-Gilloise (11) and Standard Liège (10). It is currently ranked 10th in the UEFA rankings of leagues based on performances in European competitions over the last five-years. The competition was ranked 3rd when the UEFA first published their ranking in 1979 and also the next year in 1980, which is the best ranking the Belgian First Division has ever achieved.
The first league in Belgian football was held in 1895–96 as a round-robin tournament with seven teams: Antwerp FC, FC Brugeois, FC Liégeois, RC de Bruxelles, Léopold Club de Bruxelles, SC de Bruxelles and Union d'Ixelles. FC Liégeois became the first champion of Belgium. The first eight titles in Belgian football were all won by FC Liégeois or RC de Bruxelles. There was no promotion and relegation system at the time but the last two clubs of the league (being FC Brugeois and Union d'Ixelles) withdrew and a new club entered the competition (Athletic and Running Club de Bruxelles). During the 1896–97 season, SC de Bruxelles withdrew so the 1897–98 season was played by five clubs only. In the seasons 1898–99 and 1899–1900, the football association introduced a new format with two leagues at the top level and then a final game in two legs. The format though changed back to one league with nine clubs in 1900–01 and then again to two leagues from 1901–02 to 1903–04, this time with a final round among the top two teams of each league. In 1904–05 the championship was organised with one league of 11 teams. Athletic and Running Club de Bruxelles withdrew during the season and, from the 1906 season on, a system of promotion and relegation was introduced with the winner of the second division replacing the last-placed team of the first division.
In 1906–07, Union Saint-Gilloise won their fourth consecutive title as RC de Bruxelles had from 1899–1900 to 1902–03. Both clubs claimed the next three titles before CS Brugeois won their first title, finishing one point ahead their rival of FC Brugeois. At the end of the 1907–08 season, the number of teams in the first division was increased from 10 to 12 clubs, with Promotion champion RC de Gand and runner-up ESC Forest being promoted while no first division was relegated. As World War I approached, Daring Club de Bruxelles confirmed its status of challenger, even winning the title in 1911–12 and 1913–14. Only Union Saint-Gilloise could face them in that period, winning the 1912–13 championship with a better goal difference. Since 1911–12, two clubs are relegated each year to the Promotion and two clubs from the Promotion are promoted.
During World War I, the football championship was suspended. It resumed in 1919–20 with FC Brugeois claiming their first title after 5-second places, among which were 2 lost final games and one lost test-match. At the end of the 1920–21 season, the number of teams was increased from 12 to 14, with only Uccle Sport, the last-placed team of the first division, being relegated, and the first 3 teams from the Promotion being promoted (Standard Club Liégeois, FC Malinois and RSC Anderlechtois). From 1921–22 to 1931–32, the decade was dominated by teams from the province of Antwerp: Beerschot AC, with Raymond Braine, won their first 5 titles, Antwerp FC their first 2 and the small club of Liersche SK (led by striker Bernard Voorhoof) won their first one in 1931–32. The challengers at the time were CS Brugeois (two titles in that period), Union Saint-Gilloise (one title), Daring Club de Bruxelles and Standard Club Liégeois. Starting 25 December 1932, Union Saint-Gilloise had a record 60 games unbeaten run in the championship (spanning 3 seasons), winning the 1932–33, 1933–34 and 1934–35 titles. The rival of Union during this period was Daring Club de Bruxelles. They claimed the next two championships. Following the come-back of player Raymond Braine to Beerschot, the Antwerp club won the last two titles before World War II.
On 10 May 1940 German troops invaded Belgium and the seasons 1939–40 and 1940–41 were suspended. The competition resumed in September 1941 and Liersche SK won their second title. At the end of the season, no club was relegated and the number of clubs was increased from 14 to 16. The next season, Liersche SK lost three key players (two of them in a bomb attack and the other one due to a heavy injury sustained on the pitch) and they ended at 3rd place while the neighbours of KV Mechelen became champion for the first time in their history. In 1943–44, Antwerp FC won the title. The league was suspended again in 1944–45 because of World War II.