Gambotto-Burke has written one novel, The Pure Weight of the Heart, two anthologies, Lunch of Blood and An Instinct for the Kill, a memoir, The Eclipse: A Memoir of Suicide, and Mama: Love, Motherhood and Revolution.
Gambotto-Burke was born in North Sydney and moved to East Lindfield on Sydney's North Shore at the age of four, the first child and only daughter of the late Giancarlo Gambotto, whose High Court win against WCP Ltd. changed Australian corporate law, made the front pages of The Australian Financial Review and The Australian, is still featured in corporate law exams, and was the subject of a book edited by Ian Ramsay, Professor of Law at Melbourne University.
Gambotto-Burke was first published in The Sydney Morning Herald at the age of sixteen – a satire of poet Les Murray's "An Absolutely Ordinary Rainbow", later included in Michele Field's anthology Shrinklit (1983). She was first published in The Australian at the age of eighteen. Her first short story was published in literary magazine Billy Blue Magazine in July 1982.
The Sydney Morning Herald named her as a member of Mensa International.
In 1984, at the age of 19, she moved to London, where she was employed as a music critic by NME and where, on the advice of an editor, she wrote under the pseudonyms Antonella Black and Ginger Meggs. Her review of Cliff Richard's concert inspired him to sue the music journal. She also wrote "A Man Called Horse", an unflattering cover story of alternative rock star Nick Cave, in which she documented his heroin-induced stupor (in retaliation, he wrote a song about her and British journalist Mat Snow entitled "Scum"; a photograph of Gambotto-Burke and Snow was published with Snow's account of the story in The Guardian). Gambotto-Burke wrote about the experience most recently in September 2006, and the interview has been reprinted for the third time in Nick Cave: Sinner, Saint. The Cave interview, and the story behind it, are also included in her book Lunch of Blood, while Nick Cave and the Bad Seeds included a version of "Scum" on their 2005 box set, B-Sides And Rarities.