Adepitan was born in Maryland, Lagos, Nigeria on 27 March 1973. At the age of six months, Adepitan contracted polio which resulted in the loss of function of his left leg, and ultimately prevented him from walking.
At the age of three, Adepitan and his mother emigrated to Newham, London, to join his father. He was educated at Southern Road Primary School in Plaistow which he credits with helping him with his disability and problems at home. From an early age, he had aspirations of becoming an international sportsman. He also attended Lister Community School.
Adepitan is an accomplished wheelchair basketball player, for his club Milton Keynes Aces and as a member of Great Britain team that won the bronze medal at the 2004 Summer Paralympics in Athens and the gold medal at the 2005 Paralympic World Cup in Manchester.
Adepitan has featured on many television programmes and series as an actor, presenter or guest, particularly for the BBC. He often uses television as a platform to campaign against racism and disability discrimination. He was one of three wheelchair basketball players featured in the 2002 BBC One ident Hip-Hop. He was one of the main presenters of the children's programme Xchange produced for CBBC and has appeared in the soap opera EastEnders. He starred as wheelchair basketball coach, "Baggy Awolowo", in the TV series Desperados.
Adepitan also participated in Beyond Boundaries which was a four-part documentary in which Adepitan trekked through rainforests, deserts, rivers and mountains in Nicaragua and made his own video diary filmed in London and Spain, talking about his sporting aspirations and how he coped as a London boy living in Zaragoza unable to speak any Spanish.