The district was listed on the National Register of Historic Places in 2009 pursuant to the registration requirements for residential districts set forth in a multiple property submission study, the African Americans in Los Angeles MPS. The district was originally an all-white neighborhood. Its period of significance begins in 1930 as African Americans moved into and became the dominant demographic group in the district. The historic significance of the district is enhanced by its association with important African-American figures who lived in the district during its period of significance. Singer Ivie Anderson lived at 724 E. 52nd Place from 1930 until 1945. Anderson performed with Duke Ellington's band from 1931 to 1942 and recorded the vocals on several hit recordings, including "It Don't Mean a Thing (If It Ain't Got That Swing)" (1932), "Stormy Weather" (1933), and "I Got It Bad and That Ain't Good" (1941). Civil rights activists and journalists, Joseph and Charlotta Bass, lived at 697 E. 52nd Place in the 1930s. Charlotta Bass owned and operated the California Eagle, the largest African-American newspaper on the West Coast, from 1912 to 1951.
Other buildings listed pursuant to the same African Americans in Los Angeles MPS include the Angelus Funeral Home, Lincoln Theater, Second Baptist Church, 28th Street YMCA, Prince Hall Masonic Temple, 27th Street Historic District, and two historic all-black segregated fire stations (Fire Station No. 14 and Fire Station No. 30).