This was the first year that the tournament used the so-called "pod" system, in which the eight first- and second-round sites are distributed around the four regionals. Teams were assigned to first round spots in order to minimize travel for as many teams as possible. The top seeds at each site were:
The Final Four consisted of Maryland, making their second consecutive appearance, Kansas, making their first appearance since 1993, Indiana, making their first appearance since 1992, and Oklahoma, making their first appearance since their national runner-up finish in 1988.
Maryland defeated Indiana 64-52 in the championship game to win their first ever national championship.
For the second straight tournament, the Elite Eight featured at least one double-digit seed. South Region tenth-seed Kent State and West Region twelfth-seed Missouri played in their respective regional finals, with Kent State losing to Indiana and Missouri losing to Oklahoma.
This also marked the first time since 1987 that no team from the states of North Carolina nor Kentucky reached the Final Four.